Cristiano Ronaldo, a five-time winner of the tournament, headed the hosts in the front from a primary-half of corner.
but Ajax battled stage as Donny van de Beek managed Hakim Ziyech’s shot and slotted beyond Wojciech Szczesny.
Ziyech went near after the destroy before De Ligt, up from the lower back, scored a decisive, powerful header.
The away-dreams rule left Juventus wanting inside the remaining 23 minutes, however it may had been even more at ease for the traffic within the remaining tiers with David Neres capturing extensive and Ziyech flagged offside after whipping a smart shot into the pinnacle nook.
Ronaldo, who picked up a late yellow card for a annoyed lunge at Joel Veltmans, stalked off the pitch on the very last whistle, having been knocked out of the competition for the first time due to the fact that Juventus beat his previous club real Madrid in may additionally 2015.
meanwhile, as they did after their sensational away win over real Madrid in the previous round, Ajax’s youthful side bounced in front of their raucous band of supporters and domestic fanatics streamed out the exits.
Ajax will face the winner of Manchester town and Tottenham’s sector-very last, which Spurs lead 1-0 earlier than Wednesday’s 2d leg at Etihad Stadium.